Coumarins and derivatives

Sigma Aldrich Fine Chemicals Biosciences Esculin hydrate >=98.0% (HPLC) | 531-75-9 (anhydrous) | MFCD00149492 | 50G

Esculin hydrate >=98.0% (HPLC) | Purity: >=98.0% (HPLC) | 531-75-9 (anhydrous) | MFCD00149492 | 50G

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Chem-Impex International, Inc. 7-Hydroxy-4-methylcoumarin | 90-33-5 | MFCD00006866 | 25G

7-Hydroxy-4-methylcoumarin, 90-33-5, MFCD00006866, 25G

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Medchemexpress LLC Esculetin | 305-01-1 | 99.79% | 178.14 | 1 ML

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Esculetin is an active ingredient extracted mainly from the bark of *Fraxinus rhynchophylla*. It primarily functions by inhibiting the PI3K/Akt pathway, which affects platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching. Additionally, Esculetin demonstrates antioxidant, anti-inflammatory, and antitumor properties, making it a subject of various research applications. It is intended for research use only and not for medical or patient use.

• Inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cell (ASMC) proliferation and migration.
• Demonstrates antioxidant activity.
• Exhibits anti-inflammatory effects.
• Possesses antitumor activities.
• Targets PI3K pathway.
• Induces apoptosis in certain cancer cell types.
• Ameliorates skin lesions in psoriatic mice models.

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MP Biomedicals, Inc 7-Ethoxycoumarin, MP Biomedicals™

CAS: 31005-02-4 Molecular Formula: C11H10O3 Molecular Weight (g/mol): 190.198 MDL Number: MFCD00006877 InChI Key: LIFAQMGORKPVDH-UHFFFAOYSA-N Synonym: 7-ethoxycoumarin,7-ethoxy-2h-chromen-2-one,ethylumbelliferone,2h-1-benzopyran-2-one, 7-ethoxy,7-ethoxy-2h-1-benzopyran-2-one,7-ethoxycoumarine,pubchem8680,coumarin, 7-ethoxy,acmc-209hjx PubChem CID: 35703 ChEBI: CHEBI:28184 IUPAC Name: 7-ethoxychromen-2-one SMILES: CCOC1=CC2=C(C=C1)C=CC(=O)O2

4-Bromomethyl-6,7-dimethoxycoumarin 95%, Thermo Scientific™

CAS: 88404-25-5 Molecular Formula: C12H11BrO4 Molecular Weight (g/mol): 299.12 InChI Key: JGODLBJJCNQFII-UHFFFAOYSA-N Synonym: 4-bromomethyl-6,7-dimethoxycoumarin,4-bromomethyl-6,7-dimethoxy-2h-chromen-2-one,4-bromomethyl-6,7-dimethoxychromen-2-one,2h-1-benzopyran-2-one, 4-bromomethyl-6,7-dimethoxy,4-bromomethyl-6,7-dimethoxy coumarin,4-bdmc,brdmc-4,6,7,4-bromomethyl-6,7-dimethoxy-2-oxo-2h-benzopyran PubChem CID: 128870 IUPAC Name: 4-(bromomethyl)-6,7-dimethoxychromen-2-one SMILES: COC1=C(C=C2C(=C1)C(=CC(=O)O2)CBr)OC

DL-3-(α-Acetonyl-4'-chlorobenzyl)-4-hydroxycoumarin 98%, Thermo Scientific™

CAS: 81-82-3 Molecular Formula: C19H15ClO4 Molecular Weight (g/mol): 342.78 MDL Number: MFCD00012094 InChI Key: HENZOLWOIZODCT-UHFFFAOYNA-N Synonym: coumachlor,ratilan,tomorin,cumachlor,coumachlore,cumachloor,kumachlor,geigy rodenticide exp. 332,kumachlor czech,cumachloor dutch PubChem CID: 54682651 ChEBI: CHEBI:80741 IUPAC Name: 3-[1-(4-chlorophenyl)-3-oxobutyl]-2-hydroxy-4H-chromen-4-one SMILES: CC(=O)CC(C1=CC=C(Cl)C=C1)C1=C(O)OC2=CC=CC=C2C1=O

MP Biomedicals, Inc Dimethyl Esculetin, MP Biomedicals

CAS: 120-08-1 Molecular Formula: C11H10O4 Molecular Weight (g/mol): 206.20 MDL Number: MFCD00006871 InChI Key: GUAFOGOEJLSQBT-UHFFFAOYSA-N Synonym: scoparone,6,7-dimethoxycoumarin,6,7-dimethylesculetin,escoparone,scoparon,aesculetin dimethyl ether,esculetin dimethyl ether,6,7-dimethoxy-2-benzopyrone,scopoletin methyl ether,6,7-dimethoxybenzopyran-2-one PubChem CID: 8417 ChEBI: CHEBI:9055 IUPAC Name: 6,7-dimethoxy-2H-chromen-2-one SMILES: COC1=C(OC)C=C2C=CC(=O)OC2=C1

7-[(Chlorocarbonyl)methoxy]-4-methylcoumarin 98%, Thermo Scientific™

CAS: 91454-65-8 Molecular Formula: C12H9ClO4 Molecular Weight (g/mol): 252.65 InChI Key: CTSWCAAFHPVFFO-UHFFFAOYSA-N Synonym: 7-chlorocarbonylmethoxy-4-methylcoumarin,7-chlorocarbonyl methoxy-4-methylcoumarin,7-ccmmc,2-4-methyl-2-oxochromen-7-yloxy acetyl chloride,2-4-methyl-2-oxochromen-7-yl oxy acetyl chloride,7-ccm-4-mc,acetyl chloride, 4-methyl-2-oxo-2h-1-benzopyran-7-yl oxy-, s,7-chlorocar-bonyl methoxy-4-methylcoumarin,2-4-methyl-2-oxochromen-7-yl oxyacetyl chloride,4-methyl-2-oxobenzo b pyran-7-yloxy acetyl chloride PubChem CID: 124645 IUPAC Name: 2-(4-methyl-2-oxochromen-7-yl)oxyacetyl chloride SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)OCC(=O)Cl

3-Cyanocoumarin, 97%, Thermo Scientific™

CAS: 15119-34-3 Molecular Formula: C10H5NO2 Molecular Weight (g/mol): 171.16 MDL Number: MFCD00115699 InChI Key: QKJALQPLNMEDAV-UHFFFAOYSA-N Synonym: 3-cyanocoumarin,2-oxo-2h-chromene-3-carbonitrile,coumarin-3-carbonitrile,2h-1-benzopyran-3-carbonitrile, 2-oxo,2-oxo-2h-1-benzopyran-3-carbonitrile,coumarin, 3-cyano-7ci,8ci,3-cyano-coumarin,pubchem8675,acmc-1cfdq PubChem CID: 203763 IUPAC Name: 2-oxochromene-3-carbonitrile SMILES: O=C1OC2=CC=CC=C2C=C1C#N

4-Methylumbelliferyl acetate, 99%, Thermo Scientific™

CAS: 5-9-2747 ChEBI: CHEBI:17763

MP Biomedicals, Inc DL-3-(α-Acetonylbenzyl)-4-hydroxycoumarin, MP Biomedicals

CAS: 81-81-2 Molecular Formula: C19H16O4 Molecular Weight (g/mol): 308.333 InChI Key: PJVWKTKQMONHTI-UHFFFAOYSA-N Synonym: warfarin,coumadin,coumafene,prothromadin,coumafen,coumarins,zoocoumarin,coumefene,panwarfin,warfarine PubChem CID: 54678486 ChEBI: CHEBI:87732 IUPAC Name: 4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one SMILES: CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O

7-Amino-4-(methoxymethyl)coumarin, 97%, Thermo Scientific™

CAS: 175205-10-4 Molecular Formula: C11H11NO3 Molecular Weight (g/mol): 205.21 MDL Number: MFCD00068088 InChI Key: QZZLLHOMMCKWIQ-UHFFFAOYSA-N Synonym: 7-amino-4-methoxymethyl-2h-chromen-2-one,7-amino-4-methoxymethyl coumarin,7-amino-4-methoxymethyl chromen-2-one,2h-1-benzopyran-2-one,7-amino-4-methoxymethyl,maybridge1_007060,acmc-20a3l0,7-amino-4-methoxymethylcoumarin,7-azanyl-4-methoxymethyl chromen-2-one,7-amino-4-methoxymethyl-1-benzopyran-2-one PubChem CID: 519442 IUPAC Name: 7-amino-4-(methoxymethyl)chromen-2-one SMILES: COCC1=CC(=O)OC2=CC(N)=CC=C12

6,7-Dihydroxycoumarin-3-carboxylic Acid 98.0+%, TCI America™

CAS: 84738-35-2 Molecular Formula: C10H6O6 Molecular Weight (g/mol): 222.15 MDL Number: MFCD18450959 InChI Key: STCWBNGIVIFZHI-UHFFFAOYSA-N PubChem CID: 13989553 IUPAC Name: 6,7-dihydroxy-2-oxo-2H-chromene-3-carboxylic acid SMILES: OC(=O)C1=CC2=CC(O)=C(O)C=C2OC1=O

4-Azidocoumarin 98.0+%, TCI America™

CAS: 42373-56-8 Molecular Formula: C9H5N3O2 Molecular Weight (g/mol): 187.158 InChI Key: IUICMSYHSPWQPN-UHFFFAOYSA-N PubChem CID: 375228 IUPAC Name: 4-azidochromen-2-one SMILES: C1=CC=C2C(=C1)C(=CC(=O)O2)N=[N+]=[N-]

FFN 511, Tocris Bioscience™

CAS: 1004548-96-2 Molecular Formula: C19H21F3N2O4 Molecular Weight (g/mol): 398.382 InChI Key: XHUSAIWAUAMZRG-UHFFFAOYSA-N Synonym: ffn511 tfa salt PubChem CID: 91885442 SMILES: C1CC2=C3C(=C4C(=C2)C(=CC(=O)O4)CCN)CCCN3C1.C(=O)(C(F)(F)F)O